While testing the effects of LSD in the 1950s, the US government ended up dosing a man before giving him a box full of pencils and crayons, instructing him to sketch the medical officer in the room with him. Observe and enjoy.
20 minutes after first dose:
An attending doctor observes - Patient chooses to start drawing with charcoal.
The subject of the experiment reports - "Condition normal... no effect from the drug yet."
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85 minutes after first dose:
The patient seems euphoric.
"I can see you clearly, so clearly. This... you... it's all ... I'm having a little trouble controlling this pencil. It seems to want to keep going."
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2 hours and thirty minutes after first dose:
Patient appears very focus on the business of drawing.
"Outlines seem normal, but very vivid - everything is changing colour. My hand must follow the bold sweep of the lines. I feel as if my consciousness is situated in the part of my body that's now active - my hand, my elbow... my tongue."
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2 hours and thirty-two minutes after first dose:
Patient seems gripped by his pad of paper.
"I'm trying another drawing. The outlines of the model are normal, but now those of my drawing are not. The outline of my hand is going weird too. It's not a very good drawing is it? I give up - I'll try again..."
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2 hours and thirty-five minutes after first dose:
Patient follows quickly with another drawing.
"I'll do a drawing in one flourish... without stopping... one line, no break!"
Upon completing the drawing the patient starts laughing, then becomes startled by something on the floor.
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2 hours and forty-five minutes after first dose:
Patient tries to climb into activity box (with the crayons and pencils), and is generally agitated - responds slowly to the suggestion he might like to draw some more. He has become largely non-verbal.
"I am... everything is... changed... they're calling... your face... interwoven... who is..." Patient mumbles inaudibly to a tune (sounds like "Thanks For The Memory"). He changes medium to Tempera.
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4 hours and twenty-five minutes after first dose:
Patient retreated to the bunk, spending approximately 2 hours lying, waving his hands in the air. His return to the activity box is sudden and deliberate, changing media to pen and water colour.
"This will be the best drawing, Like the first one, only better. If I'm not careful I'll lose control of my movements, but I won't, because I know. I know" - (this saying is then repeated many times).
Patient makes the last half-a-dozen strokes of the drawing while running back and forth across the room.
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5 hours and forty-five minutes after first dose:
Patient continues to move about the room, intersecting the space in complex variations. It's an hour and a half before he settles down to draw again - he appears over the effects of the drug.
"I can feel my knees again, I think it's starting to wear off. This is a pretty good drawing - this pencil is mighty hard to hold" - (he is holding a crayon).
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8 hours after first dose:
Patient sits on bunk bed. He reports the intoxication has worn off except for the occasional distorting of our faces. We ask for a final drawing which he performs with little enthusiasm.
"I have nothing to say about this last drawing, it is bad and uninteresting, I want to go home now."
Source. Directed by the wonderful Drawing On Drugs, a blog with user-submitted pictures drawn under the influence.